Combinations of growth factors for treating bone or cartilage defects

摘要

Compositions and methods of treating bone and cartilage disorders and defects consisting of applying naturally secreted growth factors to a defect site. Specifically, the present invention provides a method of treating a bone or cartilage defect comprising: culturing a living tissue, preferably skin tissue, so that the tissue secretes a plurality of growth factors; and administering the growth factor to the site of the defect. Compositions comprise a plurality of human growth factors secreted in a culture by living skin tissue. Preferably, the compositions additionally comprise a pharmaceutically-acceptable carrier. The growth factors are released onto a matrix or medium and subsequently processed for introduction to a defect site. In a preferred embodiment, the medium into which the factors are secreted is administered to the site of the defect.