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Preparation of a cephalosporin antibiotic using the synisomer of a thiazolyl intermediate
Preparation of a cephalosporin antibiotic using the synisomer of a thiazolyl intermediate
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机译:使用噻唑基中间体的同分异构体制备头孢菌素抗生素
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摘要
The present invention provides an aqueous acylation process for the preparation of antibiotic, cefepime dihydrochloride hydrate which is substantially free of the anti-isomer and the DELTA 2 isomer comprising the N-acylation of 7-amino-3-[(1-methyl-1-pyrrolidinio)-methyl]ceph-3-em-4-carboxylate with the syn-isomer of 2-(2-aminothiazol-4-yl)-2-methoxyimino acetyl chloride hydrochloride.
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