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RECOMBINANT AAV VECTORS WITH AAV5 CAPSIDS AND AAV5 VECTORS PSEUDOTYPED IN HETEROLOGOUS CAPSIDS
RECOMBINANT AAV VECTORS WITH AAV5 CAPSIDS AND AAV5 VECTORS PSEUDOTYPED IN HETEROLOGOUS CAPSIDS
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机译:带有AAV5帽的重组AAV矢量和异型囊中拟真的AAV5矢量
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摘要
A pseudotyped rAAV is described, which contains sequences derived from AAV5. A method for producing rAAV pseudotyped with AAV5 capsid is described in which the rep proteins of the serotype or any cross-reactive serotype of the AAV ITRs are utilized. A similar method may be provided to generate a pseudotyped rAAV in which minigenes carrying AAV5 ITRs are packaged in capsids of a heterologous AAV serotype. Also provided are pharmaceutical compositions containing the pseudotyped rAAV and methods of using them for gene delivery.
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