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Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids
Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids
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机译:带有AAV5衣壳的重组aav载体和异源衣壳中假型的AAV5载体
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摘要
A pseudotyped rAAV is described, which contains sequences derived from AAV5. A method for producing rAAV pseudotyped with AAV5 capsid is described in which the rep proteins of the serotype or any cross-reactive serotype of the AAV ITRs are utilized. A similar method may be provided to generate a pseudotyped rAAV in which minigenes carrying AAV5 ITRs are packaged in capsids of a heterologous AAV serotype. Also provided are pharmaceutical compositions containing the pseudotyped rAAV and methods of using them for gene delivery.
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