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Immunological and Biochemical Evaluation of the AAV Capsid to Advance Next-generation Gene Therapy Vector Design

机译：AAV Capsid推进下一代基因治疗载体设计的免疫和生化评价

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作者
Giles, April Rose.;
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作者单位

University of Pennsylvania.;

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授予单位 University of Pennsylvania.;
学科
学位 Ph.D.
年度 2018
页码 172 p.
总页数 172
原文格式 PDF
正文语种 eng
中图分类 AAI10838029;
关键词
Adeno-associated virus; Gene therapy; Viral vector;

机译：adeno相关病毒;基因治疗;病毒载体;

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1. Rationally designed capsid and transgene cassette of AAV6 vectors for dendritic cell-based cancer immunotherapy [J] . PandyaJ., OrtizL., LingC., Immunology and Cell Biology . 2014,第2期

机译：合理设计AAV6载体的衣壳和转基因盒，用于基于树突状细胞的癌症免疫治疗
2. Tolerogenic nanoparticles enhance transgene expression and intracellular vector copy number after initial and repeated administrations of AAV-based gene therapy vectors through immunological and non-immunological mechanisms [J] . Ilyinskii P. O., Michaud A., Elkins S., Human gene therapy . 2018,第12期

机译：通过免疫和非免疫机制，耐受性纳米颗粒增强初始和重复施用AAV基因治疗载体的转基因表达和细胞内载体拷贝数
3. Comparative study of liver gene therapy with AAV vectors based on endogenous and engineered AAV capsids [J] . Wang L., Bell P., Somanathan S., Human gene therapy . 2015,第10期

机译：基于内源和工程AAV衣壳的AAV载体对肝脏基因治疗的对比研究
4. Purification of Aav Gene Therapy Vectors by Selectively Inactivating Helper Adenovirus Using High Hydrostatic Pressure [C] . Antonio Delgado, Peter Ferstl, Joshua N. Leonard International Symposium on Runaway Reactions, Pressure Relief Design and Effluent Handling American Institute of Chemical Engineers/American Chemical Society Management Conference . 2005

机译：用高静压压力选择性地灭活辅助腺病毒纯化AAV基因治疗载体
5. Evaluation of viral gene expression and E3 immunomodulatory functions of adenovirus serotype 26 to inform vector design for cancer therapy [D] . Turner, Mallory AnnaMarie. 2015

机译：评估26型腺病毒的病毒基因表达和E3免疫调节功能，以指导癌症治疗的载体设计
6. Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors [O] . Katja Pekrun, Gustavo De Alencastro, Qing-Jun Luo, 2019

机译：使用带条形码的AAV衣壳库选择临床相关的基因治疗载体
7. 443. Elimination of Contaminating Capsid-Expressing Genes in AAV Vectors Reduces Immune Responses to Vector Administration in a Canine Gene Therapy Model [O] . 2013

机译：443.消除AAV载体中污染胶囊的表达基因减少了犬类基因治疗模型中对载体给药的免疫应答

Immunological and Biochemical Evaluation of the AAV Capsid to Advance Next-generation Gene Therapy Vector Design

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