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SUSTAINED-RELEASE MICROSPHERE CONTAINING ANTIPSYCHOTIC AND PROCESS FOR PRODUCING THE SAME
SUSTAINED-RELEASE MICROSPHERE CONTAINING ANTIPSYCHOTIC AND PROCESS FOR PRODUCING THE SAME
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机译:含有抑菌剂的缓释微球及其制备方法
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摘要
The present invention relates to a sustained-release microsphere comprising a hydrophobic antipsychotic such as bromperidol or haloperidol in a base made of an in vivo tissue-compatible high molecular weight polymer such as polylactic acid or lactic acid / glycolic acid copolymer, and a preparation method thereof. .;If long-term administration is required, the desired pharmacological effect can be obtained by injection once in 1 to 8 weeks instead of daily administration. As a result, a marked improvement in compliance during maintenance therapy can be expected. In addition, the use of in vivo histocompatibility high molecular weight polymers eliminates the need for any surgical procedures such as embedding, and can be easily administered subcutaneously and intramuscularly in the same manner as conventional suspension injections, so there is no need to remove them again. In addition, there is little resistance and pain at the time of administration.
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