Preparation and sustained-release testing ofchitosan/montmorillonite/acetaminophen microspheres

摘要

Chitosan (CS) is an important slow-release carrier of drugs and fertilizers. The purechitosan have poor performance, it should be added to a certain amount of crosslinking agents,emulsifiers and porogenic agents to improve the performance of it. The advantage ofmontmorillonite is no pollution and no toxicity, composite material filled in montmorillonite has anexcellent mechanical properties. In this article, CS/MMT/ACAP drug-loading microsperes wasprepared with the CS, ACAP and MMT as the main raw materials by emulsification-crosslinkingmethod. Orthogonal experiment was designed to optimize the preparation process of theCS/MMT/ACAP drug-loading microspheres. FT-IR, XRD and SEM were applied to characterizethe structure and morphology of microspheres. The sustained release effect of CS/MMT/ACAPmicrosphere was measured by sustained release measurement. The results show that theCS/MMT/ACAP drug-loading micropheres were successfully prepared byemulsification-crosslinking method. The microspheres assumed a good sphericity and a uniformparticle size distribution; the drug-loading microspheres had good sustained release effect.