84068 LB84068-Containing composition for prevention and treatment of inflammatory diseases and formulation containing thereof

摘要

PURPOSE: A composition containing LB84068 as caspase inhibitors as an effective ingredient is provided. The LB84068 is excellent in anti-inflammatory effect and can be effectively used as prophylactic and therapeutic agents for various diseases caused by inflammation, namely glomerulonephritis, rheumatoid arthritis, chronic colitis(IBD) and systemic inflammatory response syndrome. CONSTITUTION: A composition for the prevention and treatment of inflammatory disease comprises LB84068 of the formula(1), a pharmaceutically acceptable salt, a pharmacologically active material selected from the group consisting of a hydrate, a solvate or an isomer, or two or more mixtures thereof and a pharmaceutically acceptable carrier. The LB84068 has a daily dosage between about 0.3 and 100 mg/day/kg body weight. A formulation containing the composition is selected from the group consisting of tablets, soft or hard gelatin capsules, liquids, suspensions, injectable formulations, ointments, creams, gelling agents or lotions.