Inhibiting expression of target gene, useful e.g. for inhibiting oncogenes, by administering double-stranded RNA complementary to the target and having an overhang

摘要

Inhibiting expression of a target gene (I) in a cell by introducing an inhibitory RNA (dsRNA1) having a double-stranded structure of at most 49 consecutive bases, is new. At least part of one strand (as1) of dsRNA1 is complementary to (I) and at least one end of dsRNA1 has an overhang of 1-4 nucleotides (nt).