18beta, 19 beta diacetyloxy - 18alpha - 19alpha epoxy - 3.13 (16), 14 clerodatrien - 2 - one (esculentin (a) and 18beta, 19beta - diacetyloxy - 18alpha - 19alpha epoxy - 3, 12,14 - clerodatrien - 2beta - isovaleryloxy - 16beta - 7alpha diol (esculentin (b). methods for their manufacture and their use for the delivery of drugs

摘要

The invention relates to the compounds 18 beta , 19 beta -diacetyloxy-18 alpha , 19 alpha -epoxy-3, 13(16), 14-clerodatrien-2-one (Esculentin A) and 18 beta , 19 beta -diacetyloxy-18 alpha , 19 alpha -epoxy-3, 12, 14-clerodatrien-2 beta -isovaleryloxy-6 beta , 7 alpha -diol (Esculentin B) obtained from plants belonging to the Samydaceae family, particularly Casearia esculenta, a process for their preparation, and their use in the manufacture of medicaments. The compounds are particularly useful as anti-inflammatory and/or anti-cancer agents.