METHOD FOR SCREENING ACTIVE MOLECULES IN THE PREVENTION AND TREATMENT OF ATHEROSCLERIC LESIONS AND ITS APPLICATIONS

摘要

The invention concerns a method for screening and selecting active molecules for preventing and treating atherosclerotic and atheromatous lesions, products modulating the activity and the migration of cells bearing the invariant chain V alpha 15-J alpha 281 of the T-cell receptor (TCR), and their uses. Said method comprises essentially comparative detection of T V alpha 15-J alpha 281 cells present in the atherosclerotic lesions or in miming atherosclerotic lesions, in the absence or in the presence of the molecules to be tested.