AZULENE DERIVATIVE HAVING ANTI-HELICOBACTER PYLORI ACTIVITY, METHOD FOR PRODUCING THE SAME AND MEDICINE CONTAINING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide azulene derivative having sterilizing action on Helicobacter pylori bacterium and useful for treatment, prevention or recurrence prevention of digestive disorders.;SOLUTION: The present invention provides an azulene derivative represented by general formula (I) [wherein R₁ is a hydrogen atom, a (1C-8C) lower alkyl group, a benzene ring which may have a substituent group, a sulfonic acid group or a group represented by general formula (II):NHCOCH₂-B (wherein B is a naphthalene ring which may have a substituent group or an azulene group which may have a substituent group); R₂ is a hydrogen atom or a (1C-8C) lower alkyl group; A is a 1C-8C lower alkyl group or a group represented by general formula (III) (wherein R₃ is a hydrogen atom, a (1C-8C) lower alkyl or a (1C-8C) lower alkoxy group; R₄ and R₅ may be same or different and they are each independently a hydrogen atom, a (1C-8C) lower alkyl group or a benzene ring which may have a substituent group); n is 0-5] or a pharmaceutically acceptable salt.;COPYRIGHT: (C)2004,JPO&NCIPI