SMAD2 PHOSPHORYLATION AND INTERACTION WITH SMAD4

摘要

PPROBLEM TO BE SOLVED: To provide a nucleic acid which interacts with a TGF- receptor complex, and which is a negative regulator of a TGF- signaling, and to provide a peptide or the like encoded by the nucleic acid. PSOLUTION: The isolated polypeptide is a polypeptide having an amino acid sequence of Smad2 or its human homologue except that the polypeptide includes a mutation comprising a non-serine amino acid located at a position or positions selected from the group consisting of 464, 465, 467, 464 and 465, 464 and 467, and 465 and 467. Preferably, the isolated Smad2 polypeptide comprises a mutation or mutations selected from the group consisting of Ser464A, Ser465A, Ser467A, Ser464A and Ser465A, Ser464A and Ser467A, and Ser465A and Ser467A. PCOPYRIGHT: (C)2004,JPO