Method for preparing 9-amino substituted 9,10-dihydropyrrolo 2,1-B 1,3 benzothiazepine

摘要

A process is described for the preparation of compounds with the following formula where the groups are as defined below; in particular, RSUB1 /SUBis a substituted amine; said process includes essentially the reaction of pyrrolobenzothiazepin-9-one with amine RSUB1/SUBH to give the corresponding enamine, which is subsequently transformed into the final compound