General system [1](In formula, A oxygen atom and sulfur atom, to display imino basis which is possible to have possessed methylene basis or substituent which is possible to have possessed substituent, as for X halogen atom is displayed.)So in water medium and under existing of the surface active agent, attaches the difficult water soluble substance which possesses the part framework which is shown, on the radical cyclization reaction inside the molecule making use of the azo polymerization initiator which possesses dissolved in water medium and features thing the general system [2] which(In formula, as for A the same as the description above.)So production method of the chemical compound which possesses the part framework which is shown is disclosed. According to the said method, because it is possible, the radical cyclization reaction inside the molecule of the difficult water soluble substance to do in water medium, it is possible quite to decrease the adverse effect to the organism and the environment and the like which feel concern by the fact that the organic solvent is used.
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