Manipulation and detection of protein phosphatase 2C - PP2Calpha - expression in tumor cells for cancer therapy, prevention and detection

摘要

A method of detecting cancer in a patient by detecting alteration of activity of the gene coding for human type protein phosphatase 2C (PP2C and PP2C) and genetic polymorphisms thereof in a specimen isolated from the patient is disclosed. The invention further provides a method of treating cancer including the steps of first determining the type of cancer and cells expressing the cancer and then preparing a vector which will specifically target the cancer cells and can include regulatory elements to control the expressibility of PP2C. The vector is then administered to the patient. Alternatively an antisense vector can be prepared.