A polynucleotide, a Vector, a host Cell, a polypeptide, ML - 236B, method for their production, a method for Manufacturing pravastatin, an Antibody Reagent.

摘要

The polynucleotide selected from the group includes: (a) a polynucleotide, which encodes a protein, an amino acid with sequence SEQ ID 38, or a polynucleotide variant, which encodes a modified amino acid sequence with at least one substitution, addition, replacement or change, The polynucleotide variant is suitable for accelerating the biosynthesis of ml-236b; and (b) polynucleotide, which encodes the amino acid sequence of protein and SEQ ID 42 or the polynucleotide variant of the sequence into a modified amino acid sequence with at least one algebra, and an addendum,Substitution or alteration refers to such multinucleon variant that can be used to accelerate the biosynthesis of ml-236b; vector, host cell, polypeptide, ml-236b compact type, production method, production method of pravastantian, reaction antigen. Ml-236b is a HMG-CoA reduction inhibitor, which can be used to manufacture another HMG-CoA reduction inhibitor, such as pravastatina; In order to improve the preparation of ml-236b, a kind of polynucleotide was used to encode the sintetasa clustering gene.