"Pharmacological activity of (-) - hyrtiosal, (+) - hyrtiosal, (-) - 16epi - hyrtiosal and (+) - 16 - epi - hyrtiosal as antiproliferative agents.Refers to a study done to verify the biological activity of the substances synthesized, from the copu00e1lico acid in culture of human tumour cells mentioned below.The (-) - hyrtiosal (1) is, in fact, a natural product isolated from the sponge hyrtios erectus and showed activity against the cells of the antiproliferative type KB.The synthetic products 1, - 5 - 7 also had antiproliferative activity when added in culture of cells of leukemia (K562), ovary (Ovcar), kidney (786), prostate (pc03), colon (HT29)The lung (nci460), breast (MCF - 7), breast (NCI ADR resistant) and melanoma (uacc - 62), in a concentration variable for CI ~ 50 ~ 2.5 - 12 109 G / ml.
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机译：“（-）-垂体，（+）-垂体，（-）-16epi-垂体和（+）-16-Epi-垂体作为抗增殖剂的药理活性。是指为验证其的生物学活性而进行的研究。由以下提到的人类肿瘤细胞培养物中的铜酸合成的物质。（-）-垂体（1）实际上是从海绵体直立体中分离出的天然产物，对抗增殖细胞表现出活性当添加到白血病（K562），卵巢（Ovcar），肾脏（786），前列腺（pc03），结肠（HT29）的细胞培养物中时，合成产物1--5-7也具有抗增殖活性。 nci460），乳腺（MCF-7），乳腺（NCI ADR耐药）和黑色素瘤（uacc-62），其浓度变量为CI〜50〜2.5-12 <109> G / ml。
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