"The process of su00ecntese anti tumour compounds: (-) - hyrtiosal, (+) - hyrtiosal, (-) - 16 - epi - hyrtiosal and (+) - 16 - epi - hyrtiosal".Refers to the preparation of a natural product of marine origin and their stereoisomers from the copu00e1lico acid.Isolated from the commercial copaiba oil containing the two forms enantiomu00e9ricas, i.e., the acid (+) and (-) - copu00e1lico copu00e1lico.The (-) - hyrtiosal is the natural product isolated from the methanol extract of marine sponge hyrtios erectus by Iguchi and colab. [J. org.Chem 57: 522 - 524 (1992)], and has antiproliferative activity against the cells of the type KB (CI ~ 50 ~ 3 - 10 109 G / ml).In this case we 're communicating the synthesis of (-) - hyrtiosal its enantiomer of (+) - hyrtiosal, and its epu00edmeros in C - 16, (-) - 16 - epi - hyrtiosal and (+) - 16 - epi - hyrtiosal,From the acid ( sym ) - copu00e1lico in 11 steps.The total income for each isomer were: 4.8% to (-) - hyrtiosal (1), 4.2% for (+) - hyrtiosal (2), 6.8% to (-) - 16 - epi - hyrtiosal (22) and 6.0% for (+) - 16 - epi - hyrtiosal (23).
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