Compound, its pharmaceutically acceptable hydrolyzable salts, solvates and esters, pharmaceutical composition, use of a compound, and method of treating an hppar alpha-mediated disease or condition

摘要

"COMPOUND, ITS SALTS, SOLVATES AND PHARMACEUTICALLY ACCEPTABLE HYDROLYVABLE ESTERS PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND, AND METHOD OF TREATING A DISEASE OR CONDITION MEDIATED BY HPPAR ALPHA". A compound of formula (I) and pharmaceutically acceptable hydrolysable salts, solvates and esters thereof, wherein R 1 and R 2 are independently H or C 1-3 alkyl or R 1 and R 2 and R 2 which are attached to the same carbon atom may together with the carbon atom to which they are attached form a 3 to 5 membered cycloalkyl ring; X 1 represents O or S; each R 3, R 4, R 8 and R 9 independently represents H, halogen, -CH 3 and OCH 3; R 5 is H or C 1-6 alkyl or R 4 and R 5 together form a 3 to 6 membered cycloalkyl ring. X 2 represents NH, NCH 3 or O; one of Y and Z is N, and the other is O or S; R6 is phenyl or pyridyl (where N is in position 2 or 3) and is optionally substituted by one or more halogen, CF3-, straight or branched C1-6 alkyl (optionally substituted by halogen) provided that when R 6 is pyridyl, N is not substitutable. R 7 'represents C 1-6 alkyl, (optionally substituted by one or more halogens), 5-membered C 0-6 -heteroaryl alkyl, C 0-6 alkyl (O) -N- phenyl, where n is 0 or 1, provided that when R ^ 1 ^ and R ^ 2 ^ are methyl, R ^ 8 ^ and R ^ 9 ^ are H, R ^ 5 ^ for H, then R ^ 7 ^ cannot be CH ~ 3 ~ or CF ~ 3 ~.