Compound and its pharmaceutically acceptable hydrolyzable salts, solvates and esters, pharmaceutical composition, use of a compound, and method of treating an hppar alpha-mediated disease or condition in a patient

摘要

"Compound and its pharmaceutically acceptable salts, solvates and hydrolysable esters, pharmaceutical composition, use of a compound, and method of treating a disease or condition mediated by HPPAR ALPHA". A compound of formula (I) and its pharmaceutically acceptable hydrolysable salts, solvates and esters of formula I, wherein X 1 represents O or S; R 1 and R 2 are independently H or C 1 to C 3 alkyl or R 1 and R 2 which are attached to the same carbon atom may together with the carbon atom to which they are attached. they are bound to form a 3-5 membered cycloalkyl ring, R 3 R 3 and R 4 independently represent H, halogen, CH 3 and OCH 3, R 5 5 represents H or C 1-6 alkyl. C6-6, X-6 represents NH, NCH3-, or O; one of Y and Z is N, and the other is O or S; R6 is phenyl or pyridyl (where N is in position 2 or 3) and is optionally substituted by one or more halogen, CF3-, straight or branched C1-6 alkyl (optionally substituted by halogen) provided that when R6 is pyridyl, N is not substituted.