COMBINATION THERAPY FOR TREATMENT OF REFRACTORY DEPRESSION

摘要

1. A method for treating a patient suffering from or susceptible to treatment resistant major depression, comprising administering to said patient an effective amount of a first component, which is olanzapine or a pharmaceutically acceptable salt thereof in combination with an effective amount of a second component, which is fluoxetine or a pharmaceutically acceptable salt thereof. 2. A method for treating a patient suffering from or susceptible to treatment resistant major depression comprising administering to said patient an effective amount of a first component, which is olanzapine in combination with an effective amount of a second component, which is hydrochloride fluoxetine. 3. A method of claim 1, where administration of the compounds is oral. 4. A method of claim 1, wherein the ratio of olanzapine to fluoxetine by weight is selected from the group consisting of 1/5, 6/25, 12.5/25, 25/50, 17.5/50 and 25/75. 5. A method for treating a patient partially responding to treatment of major depression comprising administering to said patient an effective amount of a first component, which is olanzapine or a pharmaceutically acceptable salt thereof in combination with an effective amount of a second component, which is fluoxetine or a pharmaceutically acceptable salt thereof. 6. A method for treating a patient partially responding to treatment of major depression comprising administering to said patient an effective amount of a first component, which is olanzapine in combination with an effective amount of a second component, which is hydrochloride fluoxetine. 7. A method of claim 5, where administration of the compounds is oral. 8. A method of claim 5, wherein the ratio of olanzapine to fluoxetine by weight is selected from the group consisting of 1/5, 6/25, 12.5/25, 25/50, 17.5/50 and 25/75. 9. A method for attenuating the adverse events associated with treating a patient suffering from or susceptible to treatment resistant major depression, or partially responding to treatment of major depression, comprising administering to said patient an effective amount of a first component, which is olanzapine in combination with an effective amount of a second component, which is fluoxetine. 10. A method of claim 9, where administration of the compounds is oral. 11. A method of claim 9, wherein the ratio of olanzapine to fluoxetine by weight is selected from the group consisting of 1/5, 6/25, 12.5/25, 25/50, 17.5/50 and 25/75.