Taiazole or oxazole derivatives which are useful in treatment of cardiovascular and related diseases

摘要

A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereofWhereinR1 and R2 are independently H or C1-3 alkyl or R1 and R2 which are bonded to the same carbon atom may together with the carbon atom to which they are bonded form a 3-5 membered cycloalkyl ring;X1 represents O or S;Each R3, R4, R8 and R9 independently represents H, halogen, -CH3 and -OCH3;R5 represents H or C1-6 alkyl or R4 and R5 together form a 3-6 membered cycloalkyl ring.X2 represents NH, NCH3 or O;One of Y and Z is N, and the other is O or S;R6 represents phenyl or pyridyl (wherein the N is in position 2 or 3) and is optionally substituted by one or more halogen, CF3, C1-6 straight or branched alkyl (optionally substituted by halogen), with the provision that when R6 is pyridyl, the N is unsubstituted.R7 represents C1-6alkyl, (optionally substituted by one or more halogens), -C0-8alkyl-5 membered heteroaryl, C0-6alkyl-(O)n-phenyl, wherein n is 0 or 1, with the proviso that when R1 and R2 are methyl, R8 and R9are H, R5 is H, then R7 cannot be CH3 or CF3.