Research progress in the treatment of cardiovascular diseases based on mTOR regulating autophagy

摘要

Cardiovascular diseases(CVDs)is a major medical problem in the 21st century.Although the current treatments are rich and diverse,they have not achieved satisfactory results in prevention and treatment.The treatment of CVDS needs to find a wider and effective treatment target and direction.Autophagy is a metabolic process that degrades macromolecules.It can degrade damaged organelles,specific macromolecules,and invaded viruses and bacteria.Autophagy is widely involved in the body's metabolism and immunity,and is closely related to cardiovascular diseases.mammalian target of rapamycin(mTOR)is an atypical serine/threonine kinase,a major regulator of autophagy,can regulate the metabolism of cells and proteins in the body,and is widely involved in the occurrence and development of cardiovascular diseases.This article summarizes the relevant content of Chinese and Western medicine on mTOR regulation of autophagy in CVDS in recent years at home and abroad,in order to provide a reference for follow-up research.