Metabotropic glutamate receptor antagonists for treating tolerance and dependency

摘要

An antagonist of the metabotropic glutamate receptor 5(mGluR5) that is useful in tolerance or dependence therapy is disclosed. Such an antagonist can be used in the treatment of substance tolerance or dependence, bulimia nervosa, anorexia nervosa, gambling dependence, sex dependence or obsessive compulsive disorders.