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IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDOS FOR GABA RECEPTORS.
IMIDAZO-PYRIDINE DERIVATIVES AS LIGANDOS FOR GABA RECEPTORS.
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机译:咪达唑胺吡啶衍生物作为加巴受体的配体。
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摘要
A compound of ** formula ** or one of its salts in which Y represents a chemical bond, or a union of methylene (CH2), carbonyl (C = O), thiocarbonyl (C = S) or amide (CONH or NHCO ); Z represents an optionally substituted aryl, heteroaryl or heteroaryl-C 1-6 alkyl group, or a group of the formula -NR1R2; R1 and R2, independently, represent hydrogen, hydrocarbon or a heterocyclic group; or R1 and R2, together with the nitrogen atom involved, represent an optionally substituted heterocyclic ring selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl and thiomorpholinyl; and R3 represents an aryl or heteroaryl group, any of which may be optionally substituted.
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机译:**式**的化合物或其盐之一,其中Y表示化学键,或亚甲基(CH2),羰基(C = O),硫代羰基(C = S)或酰胺(CONH或NHCO)的结合; Z代表任选取代的芳基,杂芳基或杂芳基-C 1-6烷基,或式-NR 1 R 2的基团; R 1和R 2独立地代表氢,烃或杂环基; R 1和R 2与所涉及的氮原子一起表示选自氮杂环丁烷基,吡咯烷基,哌啶基,哌嗪基,吗啉基和硫代吗啉基的任选取代的杂环; R 3代表芳基或杂芳基,其中任何一个可以任选地被取代。
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