FLUORINATED QUINOLINE INDOLES AS INHIBITORS OF THE BIOSYNTHESIS OF LEUKOTRIENES

摘要

This invention relates to compouds having formula (I), wherein R1 is H, F orMeO, which are inhibitors of leukotrienebiosynthesis. These compounds are useful as anti-asthmatic, anti-allergic,anti-inflammatory, and cytoprotective agents.They are also useful in treating diarrhea, hypertension, angina, plateletaggregation, cerebral spasm, premature labor,spontaneous abortion, dysmenorrhea, and migraine.