MOUSE DEFICIENT IN GLUTAMATE TRANSPORTER GLAST FUNCTION

摘要

It is intended to provide a GLAST knockout mouse lacking the function ofendogenous glutamate transporter GLAST gene which shows: 1) an ocular tensionwithin the normal range; and 2) a decrease in retinal ganglion cell countcompared with a normal wild type mouse. Owing to the ocular properties, thisknockout mouse is useful as a normal tension glaucoma model. By using thisknockout mouse, a compound useful in treating normal tension glaucoma can bescreened.