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Single nucleotide polymorphisms predicting adverse drug reactions and drug efficacy in cardiovascular disease
Single nucleotide polymorphisms predicting adverse drug reactions and drug efficacy in cardiovascular disease
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机译:单核苷酸多态性预测心血管疾病的不良药物反应和药物疗效
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摘要
The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.;The present invention further relates to isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response, the polynucleotide is selected from the group comprising:SEQ ID 1-168 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for PA gene polypeptide and with or without the PA gene promoter sequence.展开▼
机译:本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒,以及包括确定人类受试者在他汀类药物治疗后是否有发生不良药物反应风险或人类受试者是高反应还是低反应或良好反应的抗体的抗体。他汀类药物的代谢不良或代谢不良。本发明提供了进一步的诊断方法和试剂盒,包括确定人类受试者是否处于心血管疾病危险中的抗体。本发明还提供了多态性序列和其他基因。本发明进一步涉及编码表型相关(PA)基因多肽的分离的多核苷酸,其可用于鉴定治疗剂的方法和可用于制备治疗心血管疾病或影响药物的药物响应,多核苷酸选自: SEQ ID 1-168,具有序列部分所示的等位基因变异,包含在功能区如PA基因多肽的全长cDNA中,并带有或没有PA基因启动子序列。 ListItem> UnorderedList>
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