OLIGOMERIC COMPOUNDS HAVING MODIFIED BASES FOR BINDING TO CYTOSINE AND URACIL OR THYMINE AND THEIR USE IN GENE MODULATION

摘要

The present invention provides modified oligomeric compounds that modulate gene expression via an RNA interference pathway. The oligomeric compounds of the invention include one or more cross-linkages that can improve nuclease resistance or modify or enhance the pharmacokinetic and phamacodynamic properties of the oligomeric compound.