Method for providing natural therapeutic agents with high therapeutic index

摘要

A method for providing new therapeutic agent(s) that comprises the following steps:a) selecting at least one polypeptide encoded by a natural allelic variant of one preselected gene with therapeutic potential and/or of at least one related gene(s) thereof;b) determining the therapeutic index of the polypeptide(s) selected in step a); andc) retaining as a therapeutic agent(s), the polypeptide(s) selected in step a), whose therapeutic index, as determined in step b), is higher than a therapeutic index of reference.