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REGULATION OF TRANSGENE EXPRESSION FOLLOWING AAV TRANSDUCTION
REGULATION OF TRANSGENE EXPRESSION FOLLOWING AAV TRANSDUCTION
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机译:AAV转化后转基因表达的调控
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摘要
The present invention provides for methods regulating gene expression both in vitro and in vivo. Specifically, the present invention provides for methods of using adeno-associated virus for transduction of a target gene in a variety of tissues wherein the expression of the transgene is regulated by administration of a proteasome inhibitor. As an example, a therapeutic gene can be delivered in vivo by an adeno-associated virus to a tissue that is not normally transduced by adeno-associated virus. The host would then be administered a proteasome inhibitor in order to induce expression of the therapeutic gene. Hence, the proteasome inhibitor would be administered only when gene expression is desired.
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