BENZOHETEROCYCLIC DISTAMYCIN DERIVATIVES, PROCESS FOR PREPARING THEM, AND THEIR USE AS ANTITUMOR AND ANTIVIRAL AGENTS

摘要

PCT No. PCT/EP97/05986 Sec. 371 Date May 4, 1999 Sec. 102(e) Date May 4, 1999 PCT Filed Oct. 23, 1997 PCT Pub. No. WO98/21202 PCT Pub. Date May 22, 1998Benzoheterocyclic distamycin derivatives of formula (I) wherein: n is 2, 3 or 4; A is O, S, or NR, wherein R is hydrogen or C1-C4 alkyl; B is CH or N; R1 is hydrogen or C1-C4 alkyl; T is selected from; (i) formula (II) wherein: p is zero or 1; R2 and R3 are selected, each independently, from: hydrogen, C1-C4 alkyl optionally substituted by one or more fluorine atoms, and C1-C4 alkoxy; R4 is C1-C4 alkyl or C1-C3 haloalkyl; X1 is a halogen atom; and (ii) formula (III) wherein X2 is a halogen atom; and pharmaceutically acceptable salts thereof, are described. Such compounds are useful as antineoplastic and antiviral agents.