HYALURONIC ACID CONTAINING BIOCONJUGATES : TARGETED DELIVERY OF ANTI-CANCER DRUGS TO CANCER CELLS

摘要

A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors overexpressed on cancer cell surface. The invention relates to compounds composed of a carrier molecule, wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one residue of a hyaluronic acid. The invention also relates to methods of making and using the compounds thereof.