AGENT CONTROLLING THE PRODUCTION OF OSTEOCLAST FORMATION REGULATOR AND METHOD OF SCREENING SUBSTANCE CAPABLE OF CONTROLLING THE PRODUCTION OF OSTEOCLAST FORMATION REGULATOR

摘要

The present invention has the object to provide an agent for controlling the production of osteoprotegerin (OPG) and a method for screening substances capable of controlling the production of OPG, and it solves the object by providing the agent for controlling the production of OPG, which comprises a saccharide as an effective ingredient; and a method for screening a substance capable of controlling the production of OPG, which comprises the steps of culturing an established cell line capable of producing OPG in a nutrient culture medium; adding a test sample to the cell culture; culturing the cells in the presence of the test sample to produce OPG; assaying the production level of OPG in the culture supernatant; and judging the test sample to be a positive substance that can control the production of OPG when the production level of OPG for the test sample is higher or lower than that for a control system.