4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2

摘要

The inventione relates to a compound of formula (I), wherein V is H or, or, R1 can be independently H, alkyl, alkenyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, N-R6R7, N- (CO) R6R7, N-R6 (CO) R7 or N- (CO) -O-R6R7 , R8 can be independently H, alkyl, alkenyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, N-R3R4, N- (CO) R3R4, N-R3 (CO) R4, N- (CO) -O-R3R4, O-R3, CO-R3, CO-OR3 or O-CO-R3, R2, R5, can be independently H, alkyl, alkenyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, carboxyl, Br, C1, F, CF3, R3, R4, R6, R7 can be independently H, alkyl, alkenyl, cycloalkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, alkylaryl, COOR5 and CO-R5, and may form a ring structure, X, Y, Z can be independently CH or N, and U can be independently S or NH, W can be independently NH, O or S, and racemic-diastereomeric mixtures, optical isomers, and pharmaceutically acceptable salts thereof, to a method of inhibiting the activity of one or more protein kinases by using these compounds in vitro or in cell culture, and to a pharmaceutical composition comprising such a compound and to their use as a medicament.