It is described for sensing analyte, wherein the equipment includes that interface contact element is used to set up interface and a certain amount of body fluid. The interface contact element be adapt to target analyte diffuse through the interface there is no net weight fluid transmit. A certain amount of body fluid exposure passes through micro- access to interface contact element. The equipment can also include sensing material, be suitable for sensing target analytes and at least one analysis method. It is also described using the method for the present apparatus in non-or minimally invasive monitoring technology. Figure (1) shows the equipment of non-limiting embodiment, the principle for test.
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