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METHOD FOR THE PREPARATION OF PACLITAXEL SOLID DISPERSION BY USING THE SUPERCRITICAL FLUID PROCESS AND PACLITAXEL SOLID DISPERSION PREPARED THEREBY
METHOD FOR THE PREPARATION OF PACLITAXEL SOLID DISPERSION BY USING THE SUPERCRITICAL FLUID PROCESS AND PACLITAXEL SOLID DISPERSION PREPARED THEREBY
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机译:利用超临界流体过程制备多环芳烃固体分散体的方法及其制备的多环芳烃固体分散体
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摘要
PURPOSE: Provided are a preparation method of paclitaxel solid dispersion having increased paclitaxel solubility by using supercritical fluid process and paclitaxel solid dispersion prepared thereby. The paclitaxel solid dispersion is used for the manufacture of oral and injectable paclitaxel formulations having high bioabsorption. CONSTITUTION: A preparation method of paclitaxel solid dispersion comprises the steps of: dissolving paclitaxel and pharmaceutically acceptable additives in an organic solvent to give a mixed solution thereof; spraying the mixed solution to supercritical fluid to form a particle of the mixture of the paclitaxel and additives; introducing additional supercritical fluid to the particle to remove the organic solvent; and recovering the formed particle.
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