首页>
外国专利>
PROTEIN IFNAB-BPII ELICITING ABILITY TO BIND INTERFERON-/, ITS PRECURSOR AND FUSION PROTEINS, METHOD FOR PREPARING IFNAB-BPII, DNA MOLECULES, EXPRESSING VECTOR, PHARMACEUTICAL COMPOSITION
PROTEIN IFNAB-BPII ELICITING ABILITY TO BIND INTERFERON-/, ITS PRECURSOR AND FUSION PROTEINS, METHOD FOR PREPARING IFNAB-BPII, DNA MOLECULES, EXPRESSING VECTOR, PHARMACEUTICAL COMPOSITION
FIELD: biotechnology, genetic engineering, medicine, pharmacy.;SUBSTANCE: invention reports about preparing new interferon-binding proteins that are able to modulate activity of different subtypes of interferon- and activity of interferon- also. Invention describes cloning DNA fragment encoding interferon-/-binding protein IFNAB-BPII and expression of prepared DNA fragment in host-cells with formation both corresponding polypeptide and in the form of fusion proteins. Invention proposes practical using prepared proteins as components of pharmaceutical compositions used for treatment of diseases requiring inhibition of activity of IFN- or IFN-.;EFFECT: valuable biological and medicinal properties of proteins.;13 cl, 13 dwg, 6 tbl, 16 ex
展开▼
机译：领域：生物技术，基因工程，医学，药学。;物质：有关制备新的干扰素结合蛋白的报道，该蛋白能够调节不同亚型的干扰素的活性以及干扰素的活性。本发明描述了克隆编码干扰素//结合蛋白IFNAB-BPII的DNA片段并在宿主细胞中表达制备的DNA片段，同时形成相应的多肽和融合蛋白形式。本发明提出了使用制备的蛋白质作为药物组合物的组分的实用方法，所述药物组合物用于治疗需要抑制IFN-或IFN-α活性的疾病。效果：蛋白质的有价值的生物学和药用特性; 13 cl，13 dwg，6 tbl，16 ex
展开▼
