BETA-ARYL-ALPHA-HYDROXY-SUBSTITUTED ALKYLCARBOXYLIC ACIDS, METHODS FOR THEIR PREPARING, INTERMEDIATE COMPOUNDS, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATMENT OR PROPHYLAXIS OF DISEASES BASED ON NEW COMPOUNDS

摘要

FIELD: organic chemistry, medicine, pharmacy.;SUBSTANCE: invention relates to new compounds that can be used in medicine as hypolipidemic or anti-hyperglycaemic agents. Invention describes -aryl--hydroxy-substituted alkylcarboxylic acids of the formula (I):; ; wherein R¹, R², R³ and R⁴ can be similar or different and represent hydrogen atom, hydroxy-group, (C₁-C₃)-alkyl; cycle A condensed with cycle comprising X and nitrogen atom (N) represents 6-membered aromatic cyclic structure comprising carbon atoms; X represents a heteroatom taken among oxygen and sulfur atoms; Ar represents bivalent phenylene, naphthylene or benzofuranyl; R⁵ represents hydrogen atom; R⁶ represents hydrogen atom; or R⁶ forms a bond in common with R⁵; R⁷ represents hydrogen atom or optionally substituted linear or branched (C₁-C₁₆)-alkyl; R⁸ represents hydrogen atom or optionally substituted or branched (C₁-C₁₆)-alkyl; Y represents oxygen atom or NR¹⁰ wherein R¹⁰ represents hydrogen atom, phenyl, hydroxy-(C₁-C₁₆)-alkyl; n is a whole number in the range 1-4; m = 0 or 1, or its pharmaceutically acceptable salts or pharmaceutically acceptable solvates. Also, invention describes intermediate compounds, methods for their preparing, methods for preparing compounds of the formula (I), pharmaceutical composition based on compounds of the formula (I), methods for treatment and prophylaxis of diseases based on new compounds. Invention provides preparing new compounds eliciting useful biological properties.;EFFECT: improved preparing method, valuable medicinal properties of compounds.;31 cl, 23 ex