ANTIBACTERIAL SUBSTITUTED 7-ACYLAMINO-3-(METHYL-HYDRAZONO)-METHYLCEPHALOSPORINS, METHOD OF THEIR PREPARING, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF, INTERMEDIATE COMPOUNDS AND METHOD OF TREATMENT OF DISEASES CAUSED BY MICROORGANISMS

摘要

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of 7-acylamino-3-(methylhydrazono)-methylcephalosporin of the general formula (Is) where R⁵ means hydrogen atom or ester residue; R_2s means alkyl, aralkyl, alkenyl or alkynyl; R_3s means hydrogen atom, alkyl, aralkyl, alkenyl, alkynyl or cycloalkyl as free form, salt and/or solvate. Invention relates also to method of synthesis of compound of the formula (Is) by interaction of compound of the formula (II) with compound of the formula (III) and isolation of compounds of the formula (Is). Invention relates also to pharmaceutical composition comprising compound of the formula (Is) with at least one pharmaceutical carrier or vehicle that shows an antibacterial effect. Invention relates also to method of treatment of patients with diseases induced by microorganisms that involves administration to patient needing this treatment the effective dose of compound of the formula (Is). Invention provides synthesis of novel compounds exhibiting an antibacterial activity. EFFECT: improved method of synthesis and treatment, valuable medicinal properties of compounds. 9 cl, 3 tbl