;or its pharmaceutically acceptable salt wherein R1 means hydrogen atom (H), CH3 or CH2OH; R2 means CH3, CH2CH3; R3 means hydrogen atom (H), (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl, halogen atom; R4 means hydrogen atom (H), (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl or halogen atom; R5 means hydrogen atom (H) or halogen atom; R6 and R7 are similar or different and mean hydrogen atom (H), (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl or (C1-C6)-alkoxy-substituted (C1-C6)-alkyl; X represents NH or oxygen atom (O). These compounds inhibit exogenously or endogenously stimulated secretion of gastric acid and, therefore, can be used for prophylaxis and treatment of gastrointestinal inflammatory diseases. Invention describes also methods for their preparing, intermediates compounds, pharmaceutical preparations based on thereof, methods for inhibition of secretion of gastric acid, treatment of gastrointestinal inflammatory diseases and treatments of states associated with Helicobacter pylori infection.;EFFECT: improved preparing method, valuable medicinal properties of compounds.;26 cl, 49 ex"/>
DERIVATIVES OF IMIDAZOPYRIDINE, METHODS FOR THEIR PREPARING AND INTERMEDIATE COMPOUNDS, PHARMACEUTICAL PREPARATION BASED ON THEREOF (VARIANTS), METHOD FOR INHIBITION OF GASTRIC ACID SECRETION, METHOD FOR TREATMENT OF GASTROINTESTINAL INFLAMMATORY DISEASES AND METHOD FOR TREATMENT OF STATES ASSOCIATED WITH HELICOBACTER PYLORI INFECTION
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DERIVATIVES OF IMIDAZOPYRIDINE, METHODS FOR THEIR PREPARING AND INTERMEDIATE COMPOUNDS, PHARMACEUTICAL PREPARATION BASED ON THEREOF (VARIANTS), METHOD FOR INHIBITION OF GASTRIC ACID SECRETION, METHOD FOR TREATMENT OF GASTROINTESTINAL INFLAMMATORY DISEASES AND METHOD FOR TREATMENT OF STATES ASSOCIATED WITH HELICOBACTER PYLORI INFECTION
DERIVATIVES OF IMIDAZOPYRIDINE, METHODS FOR THEIR PREPARING AND INTERMEDIATE COMPOUNDS, PHARMACEUTICAL PREPARATION BASED ON THEREOF (VARIANTS), METHOD FOR INHIBITION OF GASTRIC ACID SECRETION, METHOD FOR TREATMENT OF GASTROINTESTINAL INFLAMMATORY DISEASES AND METHOD FOR TREATMENT OF STATES ASSOCIATED WITH HELICOBACTER PYLORI INFECTION
FIELD: organic chemistry, medicine, pharmacy.;SUBSTANCE: invention relates to derivatives of imidazopyridine of the formula (I): ;or its pharmaceutically acceptable salt wherein R1 means hydrogen atom (H), CH3 or CH2OH; R2 means CH3, CH2CH3; R3 means hydrogen atom (H), (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl, halogen atom; R4 means hydrogen atom (H), (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl or halogen atom; R5 means hydrogen atom (H) or halogen atom; R6 and R7 are similar or different and mean hydrogen atom (H), (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl or (C1-C6)-alkoxy-substituted (C1-C6)-alkyl; X represents NH or oxygen atom (O). These compounds inhibit exogenously or endogenously stimulated secretion of gastric acid and, therefore, can be used for prophylaxis and treatment of gastrointestinal inflammatory diseases. Invention describes also methods for their preparing, intermediates compounds, pharmaceutical preparations based on thereof, methods for inhibition of secretion of gastric acid, treatment of gastrointestinal inflammatory diseases and treatments of states associated with Helicobacter pylori infection.;EFFECT: improved preparing method, valuable medicinal properties of compounds.;26 cl, 49 ex
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