CLOSED 'SENS' AND 'ANTISENSE' OLIGONUCLEOTIDS AND THEIR USE

摘要

The present invention concerns the use of a double-stranded closed oligonucleotide containing a binding site for a given transcription factor, e.g. HNF-1 factor, for inhibiting the expression of a given gene under the control of said transcription factor, e.g. liver-specific genes coding for fibrinogen, transthyretin, apolipoprotein B or the pre-S1 gene of hepatitis B virus. Particularly preferred oligonucleotides are the ones containing the sequence 5'GTTANT3', wherein N can be any of A,T,C or G.