Using polynucleotide probes based on the DPYSL3 gene (Dihydropyrimidinase-like 3), for diagnosis of psoriasis, or predisposition, and in screening for antipsoriatic agents

摘要

Use of a polynucleotide probe (A) of 10-500 bp and at least 80% complementary with a target corresponding to all or part of the DPYSL3 (Dihydropyrimidinase-like 3) gene (NM 001387.1) (a) for characterizing a biological sample by measuring the level of DPYSL3 or (b) for identifying compounds (I) for treatment of psoriasis. Independent claims are also included for the following: (1) method for identifying (I); (2) research tool or diagnostic kit that comprises (A); (3) method for diagnosing psoriasis, or a predisposition to it, by measuring overexpression of DPYSL3, by contacting a test sample with (A). ACTIVITY : Antipsoriatic. No details of tests for antipsoriatic activity are given. MECHANISM OF ACTION : Hydrolase inhibitor; Dihydropyrimidinase-like 3 inhibitor; RNAi; RNA interference; Antisense oligonucleotide inhibitor.