ASTHMATIC MODEL ANIMAL, METHOD FOR PRODUCING THE SAME AND USE THEREOF

摘要

PPROBLEM TO BE SOLVED: To provide an asthmatic model animal developing various types of bronchial asthma. PSOLUTION: An asthmatic model animal developing Th1 asthma by the stimulation of memory type Th1 cell becomes an asthmatic model animal developing Th2 asthma by the stimulation of memory type Th2 cell by using an animal having a memory type Th cell which induces asthma by stimulation. An asthmatic model animal developing mixed asthma is produced by stimulating both cells. These asthmatic model animals are useful for the precise pathologic analysis of asthma of each type and the establishment of a method for the effective treatment of asthma of various symptoms (especially the treatment of refractory bronchial asthma). PCOPYRIGHT: (C)2005,JPO&NCIPI