Mutant fab fragments of the chimeric 13B8.2 anti-CD4 antibody and their applications

摘要

A mutant Fab fragment of the 13B8.2 anti-CD4 antibody that binds a CD4 molecule and includes a mutation of at least one residue in a position situated in the VH variable domain of the heavy chain and/or in a position situated in the Vκ variable domain of the light chain.