Therapeutic and diagnostic applications of protein disulphide isomerases

摘要

An endothelial form of protein disulphide isomerase (endoPDI) is specifically upregulated in endothelial cells in response to hypoxia. Inhibition of endoPDI expression in hypoxic cells induces apoptosis. Thus the invention provides the use of endoPDI as a marker for angiogenesis and as a therapeutic target for the inhibition of angiogenesis. Agents capable of binding to or inhibiting endoPDI may be used for the detection and treatment of solid tumours.