Genetic markers and methods for the diagnosis, treatment and prevention of tumor metastasis

摘要

The multi-step nature of metastasis poses difficulties in both design and interpretation of experiments to unveil the mechanisms causing the process. In order to facilitate such studies a pair of breast tumor cell lines that originate from the same breast tumor, but have diametrically opposite metastatic capabilities have been derived. Comparison of the two cell lines has revealed a number of genes that are differentiallay expressed. The invention is the identification of these differences. The invention is the use of knowledge of the differential gene expression to develop novel therapeutic and diagnostic methods for cancer.