Interleukin-7 molecules with altered biological properties

摘要

The present invention is based, in part, on the discovery that mutating IL-7 in the region of the carboxy terminus, can result in modification of receptor ligand interactions between IL-7 and IL-7 receptor (IL-7R). Compounds that modify such interaction, which are also within the scope of the invention, can be used to treat T-cell-mediated disorders.