A process for preparing a mixture of conformers of 4 - 4 - (1R) - 4 - (trifluoromethyl) phenyl - 2-methoxyethyl - (3S) - 1-piperazinyl - methyl - 4 - methyl - 1 - 4,6 Dimethyl - 5 - pirimidinil) carbonyl, a mixture rotamer prepared by Said method, and Basic Pharmaceutical salts of said Compound

摘要

1. A procedure for manufacturing a rotary wing mixture composed of one or more rings in a salt of a basic compound, with a grinding rate higher than that of the corresponding drum in the sa The procedure includes reacting the basic compound with an acid in the mixture. The purpose of this procedure is to directly generate an unbalanced acid salt rotating cylinder relationship from 4 - [4 - [(1R) - [4 - (trifluoromethyl) phenyl] - 2-methoxy] - (3S) - methyl-1-pyridine] - 4-methyl-1 - [(4,6-dimethyl-5-pyridyl) carbides].Choose a reputable environment through creativity. This procedure is particularly helpful for the production of specific drug salts tumblers within the desired primary range of action; and for the formulation of compound salts (1);A cylindrical mixture consisting of one or more salt rings in a salt of a basic compound, the grinding rate of which is higher than that of the corresponding salt ring, and the salt preparation procedure includes reacting the basic compound with an acid mixed with a solvent.